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NAC, A Potent Antioxidant and More

By | Fact Checked |

NAC, A Potent Antioxidant and More

We live in a highly toxic world, and every second of every day we need to help protect ourselves against cell-damaging free radicals, heavy metals, environmental poisons, and other harmful substances that can cause hormone imbalances, disease, and other health concerns. NAC, which is short for N-acetyl-L-cysteine, plays a critical role in this protective process and in supporting overall health.

What is NAC?

N-Acetyl-L-cysteine is the supplement form of cysteine, a semi-essential amino acid that the body can produce from methionine and serine, two other amino acids. Cysteine is present in foods high in protein, such as legumes, seeds, eggs, chicken, and turkey. 

Read about could this amino acid change your life?

It’s important for the body to get adequate amounts of cysteine and NAC for several reasons, one of which is the building of antioxidants. The most important antioxidant is glutathione, which plays a critical role in ridding the body of harmful substances. Cysteine is a natural precursor of glutathione from foods, such as broccoli, asparagus, and cauliflower, but NAC is an immediate and more direct precursor to glutathione.

Since we are all surrounded by potentially health-damaging stuff ranging from food additives to chemicals and toxins in our cosmetics, health products, household cleaners, building materials, food storage containers, furniture, cars, and more, knowing how to protect and detox our bodies against these assaults is essential. NAC can help because it’s needed to make and replenish supplies of glutathione.

Read about 9 herbs to detox your body

How can NAC benefit menopausal women?

Women in perimenopause and menopause will find a number of reasons to make this supplement a part of their healthy routine. Here are a few examples.

  • Chronic exposure to metals in the environment, such as lead, arsenic, cadmium, and mercury, is a growing problem. These and other metals have the ability to deplete glutathione and inhibit antioxidative enzymes. NAC supplementation may help with detoxification.

Using NAC supplements

Your body makes cysteine but it needs adequate amounts of vitamins B6 and B12 as well as folate. Most foods rich in protein also contain cysteine. However, an NAC supplement can help increase cysteine intake. A 900-mg dose is typical, but talk to your healthcare provider about the dose best for your needs. 

Bottom line

NAC supplements can bring a number of health benefits to the table for women in their perimenopause and menopause years and beyond.

  • Anfossi G et al. N-acetyl-L-cysteine exerts direct anti-aggregating effect on human platelets. European Journal of Clinical Investigation 2001 May; 31(5):452-61.
  • Dröge W, Breitkreutz R. Glutathione and immune function. Proceedings of the Nutrition Society 2000 Nov; 59(4):595-600
  • Geiler J et al. N-acetyl-L-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus. Biochemical Pharmacology 2010 Feb 1; 79(3):413-20. 
  • Jain SK et al. L-cysteine supplementation lowers blood glucose, glycated hemoglobin, CRP, MCP-1, and oxidative stress and inhibits NF-kappaB activation in the livers of Zucker diabetic rats. Free Radical Biological Medicine 2009 Jun 15; 46(12):1633-38.
  • Liu C et al. N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition. BMC Cardiovascular Disorders 2015 Aug 6; 15:84.
  • Mokhtari V et al. A review on various uses of n-acetyl cysteine. Cell Journal 2017; 19(1): 11-17.
  • Nall R. What are the benefits of NAC? Medical News Today 2022 Jan 2
  • Quig D. Cysteine metabolism and metal toxicity. Alternative Medicine Review 1998 Aug; 3(4):262-70.  
  • Shackebaei D et al. Mechanisms underlying the cardioprotective effect of L-cysteine. Molecular and Cellular Biochemistry 2005 Sep; 277(1-2):27-31.
Andrea is a Registered Holistic Nutritionist (RHN) & Menopause Expert. Andrea is in menopause & has been researching for the last 5 years science-based ingredients and methods to help women manage their symptoms. She’s the Founder of NaturallySavvy.com—a multiple award-winning website. Andrea co-authored the book “Unjunk Your Junk Food” published by Simon and Schuster, as well as “Label Lessons: Your Guide to a Healthy Shopping Cart,” and “Label Lessons: Unjunk Your Kid’s Lunch Box.” Andrea co-hosts the Morphus for Menopause podcast and appears as a Healthy Living Expert on TV across North America. Andrea has more than 20 years of experience in the health & wellness space and is a multiple award-winning Influencer.