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Coenzyme Q10 For Menopause Support

By | Fact Checked |

Coenzyme Q10 For Menopause Support

If you are in perimenopause or menopause, you already know there are some changes taking place in your body, but not all of them are evident. Take the higher risk of heart disease, for example, or more fragile bones and osteoporosis. Some good news is that certain supplements can help make this transitional time of life safer and smoother, and coenzyme Q10 (CoQ10) is one of those supplements.

What is coenzyme Q10?

Coenzyme Q10 is a compound produced naturally in the body and stored in the energy-producing organelles called mitochondria that are found in your cells. One of the main tasks of CoQ10 is to produce adenosine triphosphate (ATP), which is involved in generating and transferring energy within your cells. Mitochondria also protect cells from disease-causing viruses and bacteria as well as oxidative damage. 

Coenzyme Q10 exists in two forms: ubiquinone and ubiquinol. Ubiquinol is the active antioxidant form and is produced in the body from ubiquinone. Levels of both forms can begin to decline as early as 20 years of age. This is joined by a declining ability of the body to make ubiquinol from ubiquinone. You can take a simple blood test to determine your CoQ10 levels. 

The greatest concentrations of CoQ10 are in the heart, lungs, liver, and kidneys, all of which have high energy demands. However, levels of CoQ10 tend to decrease with age and with it the health benefits it provides. Low levels of CoQ10 have been associated with heart disease, fibromyalgia, diabetes, muscular diseases, and brain disorders. 

How can coenzyme Q10 help women in menopause?

CoQ10 can help women in perimenopause, menopause, and beyond in a number of important ways.

Skin health. Declining levels of estrogen contribute to various skin problems, including dryness, itching, dullness, and wrinkles. Environmental assaults such as ultraviolet rays, air pollution, and harsh chemicals in cosmetics and healthcare products are also a factor, and their impact accumulates over time. 

The use of CoQ10 in a topical form can help reduce environmental damage as well as that associated with hormonal changes. It’s been shown in a study of topical CoQ10 to do so by promoting antioxidant protection, reducing free radicals, and enhancing mitochondrial activity in skin cells. Some experts even found that CoQ10 applied to the skin can reduce wrinkles. 

Migraines. This painful symptom may appear as a new factor with menopause or it may increase in severity in women who had them before their hormonal changes. In either case, CoQ10 supplements appear to be three times more effective than placebo at reducing the number of migraines, according to a study in Neurology

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Other research has shown that some people with migraines have a CoQ10 deficiency. Treatment with CoQ10 supplements has resulted in fewer and less severe migraines among individuals with low CoQ10 levels. This supplement may even be able to help prevent migraines, based on another study in which CoQ10 was shown to significantly reduce the frequency and severity of migraine as well as shorten the duration.

Read about natural headache and migraine remedies

Heart disease: The risk of heart disease and stroke rises in menopause and postmenopause, although menopause is not the cause of these cardiovascular conditions. The use of CoQ10 may provide “significant cardiovascular protective effects,” according to the authors of a Cardiovascular Pharmacology: Open Access article. 

The use of CoQ10 supplements may also reduce high blood pressure, which is a risk factor for heart attack. In a meta-analysis of 12 clinical trials, the authors found that CoQ10 had the ability to reduce systolic blood pressure by up to 17 mmHg and diastolic pressure by up to 10 mmHg without significant adverse effects.

Diabetes: Many women in menopause are affected by insulin resistance (and accompanying weight gain) and diabetes. CoQ10 supplementation may improve insulin sensitivity and regulate blood sugar levels. In another study, individuals with type 2 diabetes took CoQ10 supplements for 12 weeks. They experienced two important benefits: a reduction in fasting blood sugar levels and hemoglobin A1C.

Read about omega-3 fatty acids and brain health

Brain health: Brain fog, memory problems, depression, anxiety, mood swings, and stress are all symptoms of the menopause years, and it’s important to keep those brain cells functioning at an optimal level. CoQ10 helps fight the oxidative damage to the brain that can impact memory and cognitive function. The use of CoQ10 supplements may reduce free radical levels and may even slow the progression of Alzheimer’s disease.

Using CoQ10 supplements

A typical dose of CoQ10 is 90 to 200 mg, but your actual dose may vary depending on your condition and needs. Among people with heart failure, for example, a dose of 100 mg has been used in research. For diabetes, doses of 100 mg to 300 mg are typical. 

Bottom line

Symptoms as well as serious health conditions that are associated with perimenopause, menopause, and postmenopause may be alleviated by using CoQ10 supplements. Consult your healthcare provider before taking this supplement.

  • Amin MM et al. Novel CoQ10 antidiabetic mechanisms underlie its positive effect: modulation of insulin and adiponectine receptors, Tyrosine kinase, PI3K, glucose transporters, sRAGE and visfatin in insulin resistant/diabetic rats. PLoS One 2014 Feb 20; 9(2):e89169.
  • Fotino AD et al. Effect of coenzyme Q₁₀ supplementation on heart failure: a meta-analysis. American Journal of Clinical Nutrition 2013 Feb; 97(2):268-75. 
  • Galluzzi L et al. Mitochondrial control of cellular life, stress, and death. Circulation Research 2012 Oct 12; 111(9):1198-207.
  • Garrido-Maraver J et al. Clinical applications of coenzyme Q10. Frontiers in Bioscience (Landmark Ed). 2014 Jan 1; 19:619-33.
  • Hershey AD et al. Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. Headache 2007 Jan; 47(1):73-80.
  • Hoppe U et al. Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors 1999; 9(2-4):371-78.
  • Knott A et al. Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects. Biofactors 2015 Nov-Dec; 41(6):383-90.
  • Rosenfeldt FL et al. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. Journal of Human Hypertension 2017 Feb 8; 21:297-306
  • Saini R. Coenzyme Q10: The essential nutrient. Journal of Pharmacy and Bioallied Sciences 2011 Jul; 3(3):466-67.
  • Sándor PS et al. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology 2005 Feb 22; 64(4):713-15. 
  • Semeco A. 9 benefits of coenzyme Q10 (CoQ10). Healthline 2017 Oct 12
  • Shoeibi A et al. Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial. Acta Neurologica Belgica 2017 Mar; 117(1):103-9.
  • Suksomboon N et al. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. Journal of Clinical Pharmacy and Therapeutics 2015 Aug; 40(4):413-8.
  • Tillmann P, Yeung PK. Coenzyme Q10 for cardiovascular prevention. Cardiovascular Pharmacology: Open Access 2013; 3:1
  • Wadsworth TL et al. Evaluation of coenzyme Q as an antioxidant strategy for Alzheimer's disease. Journal of Alzheimers Disease 2008 Jun; 14(2):225-34
  • Zahedi H et al. Effects of CoQ10 supplementation on lipid profiles and glycemic control in patients with type 2 diabetes: a randomized, double blind, placebo-controlled trial. Journal of Diabetes and Metabolic Disorders 2014 Jul 25; 13:81.
Andrea is a Registered Holistic Nutritionist (RHN) & Menopause Expert. Andrea is in menopause & has been researching for the last 5 years science-based ingredients and methods to help women manage their symptoms. She’s the Founder of—a multiple award-winning website. Andrea co-authored the book “Unjunk Your Junk Food” published by Simon and Schuster, as well as “Label Lessons: Your Guide to a Healthy Shopping Cart,” and “Label Lessons: Unjunk Your Kid’s Lunch Box.” Andrea co-hosts the Morphus for Menopause podcast and appears as a Healthy Living Expert on TV across North America. Andrea has more than 20 years of experience in the health & wellness space and is a multiple award-winning Influencer.